SCHEMBL7075283

SCHEMBL7075283

CCCCCc1ccc(C(=O)CN2C=CSC2)cc1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
THRA P10827 12/20 0.51
THRB P10828 12/20 0.51
HAO1 Q9UJM8 1/20 0.48
RARB P10826 5/20 0.46
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
RARA P10276 1/20 0.45
MAPT P10636 1/20 0.45
MTOR P42345 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL3854822 0.99 THRA (0.50) THRATHRBHAO1RARBMEN1
Hydrochloric Acid SCHEMBL9662432 0.77 THRA (0.50) THRATHRBHAO1RARBALDH1A1
SCHEMBL6936037 0.76 GSK3B (0.44) MEN1ALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL3847435 0.75 HDAC3 (0.41) MEN1ALDH1A1MAPTKMT2A
Bromide SCHEMBL3847332 0.75 HDAC3 (0.41) MEN1ALDH1A1MAPTKMT2A
Bromide SCHEMBL2947798 0.75 RAB9A (0.46) HAO1ALDH1A1MAPTKMT2A
Bromide SCHEMBL3847336 0.75 NPC1 (0.42) MEN1ALDH1A1KMT2A
Iodide SCHEMBL10526799 0.73 THRA (0.46) THRATHRBHAO1RARBALDH1A1
SCHEMBL7137148 0.72 THRA (0.72) THRATHRBHAO1RARBMEN1
SCHEMBL10883866 0.71 THRA (0.75) THRATHRBHAO1RARBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808163-B1 USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS ALTEON INC (US) 2003-07-23 EP claimed
US-6007865-A FOR INHIBITING AND REVERSING NONENZYMATIC CROSS-LINKING (PROTEIN AGING), TREATING KIDNEY DAMAGE AND TREATING COMPLICATIONS OF DIABETES, PREVENTING FOOD SPOILAGE ALTEON INC. 1999-12-28 US claimed