Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.69 |
| ▸ | CNR2 | P34972 | 2/20 | 0.69 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.69 |
| ▸ | TUBB | P07437 | 2/20 | 0.69 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.69 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.69 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.69 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.69 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.69 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.69 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.69 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.69 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.69 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.69 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.69 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.69 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.69 |
| ▸ | ESR1 | P03372 | 9/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190469 | 0.97 | CNR1 (0.69) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075343 | 0.97 | CNR1 (0.69) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075690 | 0.95 | TUBB4A (0.60) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11547223 | 0.92 | ESR1 (0.63) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11553755 | 0.91 | CNR1 (0.61) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL5026252 | 0.91 | CNR1 (0.78) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL26625282 | 0.91 | TUBB4A (0.60) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL26625371 | 0.91 | TUBB4A (0.60) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL8625838 | 0.90 | ESR1 (0.65) | CNR1CNR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11549590 | 0.89 | CNR2 (0.88) | CNR1CNR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920863-B1 | The use of 2-Aryl-3-aroylbenzo(b)thiophenes for the treatment of estrogen deprivation syndrome | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | claimed |
| US-6156786-A | ANTIESTROGENS | ELI LILLY AND COMPANY (US) | 2000-12-05 | — | — | US | claimed |
| EP-0920863-A1 | 2-Aryl-3-aroylbenzo(b)thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | claimed |
| EP-0920863-B1 | The use of 2-Aryl-3-aroylbenzo(b)thiophenes for the treatment of estrogen deprivation syndrome | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| US-6403615-B1 | TREATS OSTEOPOROSIS, HYPERLIPIDEMIA, AND CARDIOVASCULAR DISORDERS ASSOCIATED WITH MENOPAUSE; SIDE EFFECT REDUCTION COMPARED TO ESTROGEN-REPLACEMENT THERAPY | ELI LILLY AND COMPANY | 2002-06-11 | — | — | US | disclosed |
| US-6156786-A | ANTIESTROGENS | ELI LILLY AND COMPANY (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0920863-A1 | 2-Aryl-3-aroylbenzo(b)thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |