Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 4/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071901 | 0.91 | LMNA (0.50) | HDAC4HDAC6HDAC2HDAC8LMNA | |
| SCHEMBL7074222 | 0.89 | LMNA (0.62) | L3MBTL1LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7071903 | 0.88 | LMNA (0.47) | HDAC4HDAC6HDAC2HDAC8LMNA | |
| SCHEMBL7071582 | 0.87 | LMNA (0.60) | LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7071746 | 0.87 | MEN1 (0.54) | L3MBTL1LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7075122 | 0.87 | LMNA (0.65) | HDAC4LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7132172 | 0.85 | ALDH1A1 (0.54) | LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7074809 | 0.85 | LMNA (0.53) | L3MBTL1LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7069983 | 0.85 | LMNA (0.58) | L3MBTL1LMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL7073993 | 0.84 | ALDH1A1 (0.60) | LMNAHTTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |