Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923346 | 0.80 | KMT2A (0.39) | POLBALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL7015641 | 0.73 | EGLN1 (0.55) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL16689827 | 0.73 | MEN1 (0.37) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL15154245 | 0.72 | TGFBR1 (0.42) | TGFBR1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL12887950 | 0.72 | MEN1 (0.39) | POLBALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL7214475 | 0.72 | TGFBR1 (0.45) | TGFBR1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL193660 | 0.70 | TGFBR1 (0.44) | TGFBR1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL193659 | 0.70 | TGFBR1 (0.44) | TGFBR1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL18506232 | 0.70 | TGFBR1 (0.44) | TGFBR1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL6399291 | 0.69 | CYP2D6 (0.54) | POLBALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341784-A2 | PROCESS FOR MAKING A THROMBIN INHIBITOR | Merck & Co., Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6455532-B1 | ANTICOAGULANTS | MERCK & CO., INC. | 2002-09-24 | — | — | US | disclosed |
| US-20020103379-A1 | Process for making a thrombin inhibitor | MERCK SHARP & DOHME LTD. (GB) | 2002-08-01 | — | — | US | disclosed |
| WO-2002046160-A2 | PROCESS FOR MAKING A THROMBIN INHIBITOR | MERCK & CO., INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103379-A1 | Process for making a thrombin inhibitor | TFPI, TFPI2, F2 | TGFBR1 3516/4885POLB 1750/4885ALDH1A1 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.