Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307136 | 0.81 | KDM4E (0.60) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL15642612 | 0.80 | PIN1 (0.50) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL17927550 | 0.79 | MAP3K11 (0.46) | HSD17B10ALDH1A1POLBSMN1; SMN2PDE3B | |
| SCHEMBL1486903 | 0.77 | PDE3B (0.48) | KDM4EHPGDHSD17B10ALDH1A1TDP1 | |
| SCHEMBL19538285 | 0.76 | KDM4E (0.41) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL19538219 | 0.76 | FGFR1 (0.47) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL30492866 | 0.75 | HRH4 (0.53) | KDM4EHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL1643417 | 0.74 | KMO (0.68) | KDM4EHPGDHSD17B10ALDH1A1TDP1 | |
| SCHEMBL13460613 | 0.73 | PDGFRB (0.77) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL25044341 | 0.72 | SMAD3 (0.51) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |