SCHEMBL7076434

SCHEMBL7076434

CCN(CC)CCc1c[nH]c2ccc(Cn3ccnc3)cc12

nearest known ligand 0.82

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 9/20 0.82
HTR2C P28335 5/20 0.82
HTR1D P28221 4/20 0.55
MPO P05164 2/20 0.55
TBXAS1 P24557 2/20 0.55
HTR2A P28223 3/20 0.53
HTR1B P28222 2/20 0.53
ADRA2C P18825 1/20 0.53
HRH1 P35367 1/20 0.53
HTR2B P41595 1/20 0.53
SNCA P37840 1/20 0.52
HTR6 P50406 2/20 0.50
MEN1 O00255 1/20 0.50
CYP19A1 P11511 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27374776 0.94 HTR1A (0.75) HTR1AHTR2CHTR1DMPOTBXAS1
SCHEMBL6943873 0.90 HTR1A (1.00) HTR1AHTR2CHTR1DTBXAS1HTR2A
SCHEMBL6946024 0.86 HTR1A (0.60) HTR1AHTR2CHTR1DMPOHTR2A
SCHEMBL7480332 0.84 HTR2C (0.73) HTR1AHTR2CHTR1DTBXAS1HTR2A
SCHEMBL6945754 0.83 HTR1A (0.79) HTR1AHTR2CHTR1DTBXAS1HTR2A
SCHEMBL7478876 0.82 HTR1A (0.71) HTR1AHTR2CHTR1DTBXAS1HTR2A
SCHEMBL6945835 0.80 HTR1A (0.82) HTR1AHTR2CHTR1DMPOHTR2A
SCHEMBL6941505 0.76 HTR1A (0.57) HTR1AHTR2CHTR1DMPOHTR2A
SCHEMBL6941530 0.75 HTR1A (0.75) HTR1AHTR2CHTR1DHTR2AHTR1B
SCHEMBL6942953 0.74 HTR1D (0.75) HTR1AHTR2CHTR1DMPOHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP claimed
US-5808064-A HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE MERCK & CO., INC. (US) 1998-09-15 US claimed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US claimed
EP-0763032-B1 PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE MERCK & CO INC (US) 2003-10-15 EP disclosed
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP disclosed
US-5808064-A HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE MERCK & CO., INC. (US) 1998-09-15 US disclosed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US disclosed