Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | TGM1 | P22735 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086405 | 0.88 | KMT2A (0.55) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7079810 | 0.85 | ALDH1A1 (0.59) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7077533 | 0.83 | KDM4E (0.60) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7079584 | 0.81 | ALDH1A1 (0.60) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8337431 | 0.80 | CA1 (0.58) | MEN1KMT2AALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL14477864 | 0.78 | POLB (0.53) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7077701 | 0.78 | MAPT (0.54) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7080602 | 0.78 | MAPT (0.65) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2963306 | 0.77 | ALDH1A1 (0.68) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14697013 | 0.76 | HSD17B10 (0.56) | ALDH1A1HSD17B10POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |