Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104660 | 0.83 | OPRL1 (0.61) | DRD2SIGMAR1OPRM1MAOAMAOB | |
| SCHEMBL7237582 | 0.82 | OPRM1 (0.47) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL11742871 | 0.76 | OPRM1 (0.56) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL11738755 | 0.74 | OPRL1 (0.69) | DRD2SIGMAR1OPRM1CYP2D6DRD4 | |
| SCHEMBL7243212 | 0.74 | OPRM1 (0.52) | SIGMAR1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL6956108 | 0.73 | OPRM1 (0.50) | DRD2SIGMAR1OPRM1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL11744428 | 0.73 | POLB (0.70) | DRD2SIGMAR1OPRM1CYP2D6OPRL1 | |
| SCHEMBL9385861 | 0.73 | ADRA1A (0.52) | SIGMAR1OPRM1GRIN2DGRIN3BCHRM2 | |
| SCHEMBL3867146 | 0.73 | OPRM1 (0.55) | DRD2SIGMAR1OPRM1GRIN2DGRIN3B | |
| SCHEMBL6196379 | 0.72 | CYP2D6 (0.49) | OPRM1GRIN2DGRIN3BCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | claimed |