Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072558 | 0.86 | ALDH1A1 (0.44) | AKR1C3AKR1C1KMT2AMEN1PPARG | |
| SCHEMBL23657779 | 0.80 | KMT2A (0.50) | AKR1C3KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7821841 | 0.79 | KMT2A (0.59) | AKR1C3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL30539315 | 0.79 | KMT2A (0.59) | AKR1C3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7077474 | 0.77 | KMT2A (0.63) | AKR1C3AKR1C1KMT2AMEN1PPARG | |
| SCHEMBL17227611 | 0.75 | KMT2A (0.62) | AKR1C3KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL3282591 | 0.74 | AKR1C3 (0.53) | AKR1C3AKR1C1TSHR | |
| SCHEMBL1266470 | 0.74 | AKR1C3 (0.56) | AKR1C3AKR1C1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7077782 | 0.71 | KMT2A (0.59) | AKR1C3AKR1C1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7078026 | 0.71 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003525203-A | — | — | 2003-08-26 | — | — | JP | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | claimed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |