Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076059 | 0.90 | CCR2 (0.68) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7077386 | 0.87 | CCR2 (0.56) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7080358 | 0.86 | CCR2 (0.70) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7072225 | 0.84 | CCR2 (0.73) | CCR2ABCB11 | |
| SCHEMBL7072260 | 0.84 | CCR2 (0.59) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6301048 | 0.82 | CCR2 (1.00) | CCR2ABCB11 | |
| SCHEMBL9239991 | 0.81 | CCR2 (0.67) | CCR2LMNAMAPTABCB11 | |
| SCHEMBL7072264 | 0.80 | CCR2 (0.52) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7072428 | 0.79 | CCR2 (0.53) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7072061 | 0.79 | CCR2 (0.58) | CCR2ALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |