SCHEMBL7077972

SCHEMBL7077972

CCC(C1CCN(c2ccc(Nc3ncc4c(C)c(F)c(=O)n(C(C)C)c4n3)cc2Cl)CC1)C1CNCCN1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 9/20 0.45
CCND1 P24385 7/20 0.45
CCND2 P30279 7/20 0.45
CCND3 P30281 7/20 0.45
PAK3 O75914 1/20 0.41
PAK4 O96013 1/20 0.41
LIMK1 P53667 1/20 0.41
LIMK2 P53671 1/20 0.41
PAK1 Q13153 1/20 0.41
PAK2 Q13177 1/20 0.41
PKN1 Q16512 1/20 0.41
CAMK2D Q13557 1/20 0.40
WEE1 P30291 2/20 0.39
CCNE2 O96020 3/20 0.39
CCNA2 P20248 3/20 0.39
CCNE1 P24864 3/20 0.39
CDK2 P24941 3/20 0.39
CCNA1 P78396 3/20 0.39
EGFR P00533 4/20 0.38
TNK2 Q07912 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6939792 0.90 CDK4 (0.57) CDK4CCND1CCND2CCND3CCNE2
SCHEMBL6941999 0.84 CDK4 (0.57) CDK4CCND1CCND2CCND3PAK3
SCHEMBL6943074 0.81 CDK4 (0.72) CDK4CCND1CCND2CCND3CCNB2
SCHEMBL7070107 0.80 CDK4 (0.71) CDK4CCND1CCND2CCND3CCNB2
SCHEMBL6942006 0.73 CDK4 (0.56) CDK4CCND1CCND2CCND3PAK3
SCHEMBL6940711 0.70 CDK4 (0.77) CDK4CCND1CCND2CCND3PAK3
SCHEMBL6945561 0.69 CDK4 (0.65) CDK4CCND1CCND2CCND3CCNE2
SCHEMBL6942106 0.68 CDK4 (0.79) CDK4CCND1CCND2CCND3CCNE2
SCHEMBL6945592 0.67 CDK4 (0.61) CDK4CCND1CCND2CCND3CCNE2
SCHEMBL6939778 0.66 CDK4 (0.64) CDK4CCND1CCND2CCND3PAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP disclosed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO disclosed