Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079998 | 0.93 | REN (0.62) | RENGPR119FFAR1 | |
| SCHEMBL7080785 | 0.88 | REN (0.51) | RENPOLBMAPTPSMB5KMT2A | |
| SCHEMBL7077232 | 0.87 | REN (0.50) | RENFFAR1 | |
| SCHEMBL7075025 | 0.87 | REN (0.52) | RENGPR119 | |
| SCHEMBL7080728 | 0.86 | REN (0.49) | RENPOLBMAPTFFAR1PSMB5 | |
| SCHEMBL7081341 | 0.86 | REN (0.51) | RENMAPTGPR119FFAR1 | |
| SCHEMBL6043084 | 0.86 | REN (0.70) | RENPOLBMAPTKDM4EFFAR1 | |
| SCHEMBL7080921 | 0.83 | REN (0.46) | RENPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL7079873 | 0.83 | REN (0.46) | RENMAPT | |
| SCHEMBL7081694 | 0.83 | REN (0.53) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |