Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082067 | 0.88 | RAB9A (0.39) | RENNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL7079998 | 0.88 | REN (0.62) | RENNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL6958396 | 0.86 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL7080459 | 0.86 | NPC1 (0.36) | RENNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL6043947 | 0.85 | REN (0.50) | RENNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL7080924 | 0.85 | REN (0.54) | REN | |
| SCHEMBL7076956 | 0.85 | REN (0.41) | RENNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL7080921 | 0.85 | REN (0.46) | RENNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7075237 | 0.84 | REN (0.56) | REN | |
| SCHEMBL7074891 | 0.84 | REN (0.48) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |