Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753239 | 0.88 | SSTR5 (0.58) | SSTR5MCHR1DRD2DRD4SIGMAR1 | |
| SCHEMBL5752080 | 0.88 | MEN1 (0.58) | SSTR5MEN1KMT2AMCHR1DRD2 | |
| SCHEMBL5754611 | 0.86 | MAPT (0.57) | MAPTMCHR1DRD2DRD4DRD3 | |
| SCHEMBL5753042 | 0.86 | MAPT (0.57) | MAPTSSTR5MCHR1CHRM4DRD2 | |
| SCHEMBL5755013 | 0.80 | MCHR1 (0.50) | SSTR5MEN1KMT2AMCHR1DRD2 | |
| SCHEMBL5750042 | 0.78 | MAPT (0.58) | MAPTDRD2DRD4DRD3HTR1A | |
| SCHEMBL5751430 | 0.77 | DRD4 (0.52) | SSTR5MEN1KMT2AMCHR1DRD2 | |
| SCHEMBL5751064 | 0.77 | FAAH (0.54) | MCHR1CHRM4DRD2DRD4DRD3 | |
| SCHEMBL6031666 | 0.75 | MAPT (1.00) | MAPTMEN1KMT2ADRD2DRD4 | |
| SCHEMBL5752961 | 0.75 | DRD2 (0.50) | DRD2DRD4DRD3HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309586-A1 | 4-, 5-, 6- AND 7-INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002016349-A1 | 4-, 5-, 6- AND 7-INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-02-28 | — | — | WO | disclosed |