⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197286 | 0.68 | TSHR (0.32) | — | |
| SCHEMBL1429616 | 0.67 | — | — | |
| SCHEMBL10617036 | 0.67 | TSHR (0.34) | — | |
| SCHEMBL8462226 | 0.66 | MEN1 (0.33) | — | |
| SCHEMBL2045631 | 0.65 | — | — | |
| SCHEMBL2856292 | 0.63 | — | — | |
| SCHEMBL31160934 | 0.62 | — | — | |
| SCHEMBL12890115 | 0.62 | RAB9A (0.31) | — | |
| SCHEMBL1286858 | 0.61 | — | — | |
| SCHEMBL13532426 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617339-B1 | 5-Isoxazolyloxymethyl-3-((dihydroxypropanoyl)-4-tetrahydropyri dyl-3,5- difluorophenyl)oxazolidinone, or the phosphated derivative or its disodium salt; antibiotic with useful activity against Grampositive pathogens | SYNGENTA LIMITED (GB) | 2003-09-09 | — | — | US | disclosed |
| US-20030144263-A1 | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them | SYNGENTA LIMITED (GB) | 2003-07-31 | — | — | US | disclosed |