SCHEMBL9197286

SCHEMBL9197286

CCCC[Si](C)(C)ON1CCCC1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10617036 0.98 TSHR (0.34) TSHRL3MBTL1
SCHEMBL7078243 0.68
SCHEMBL17865466 0.67 TSHR (0.32) TSHR
SCHEMBL11200 0.66 TSHR (0.35) TSHR
SCHEMBL782585 0.66 LMNA (0.30) TSHR
SCHEMBL8462226 0.64 MEN1 (0.33)
SCHEMBL1260831 0.64
SCHEMBL8707053 0.64 DNM1 (0.32) TSHR
SCHEMBL4917509 0.64 TSHR (0.39) TSHRL3MBTL1
SCHEMBL1567062 0.62 TSHR (0.32) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0658162-A1 CARBAPENEM DERIVATIVES AND PROCESSES FOR PREPARING THE SAME DONG-A PHARM. CO., LTD. (KR) 1995-06-21 EP disclosed
WO-1994005667-A1 CARBAPENEM DERIVATIVES AND PROCESSES FOR PREPARING THE SAME DONG-A PHARMACEUTICAL CO., LTD. (KR) 1994-03-17 WO disclosed
WO-1993011128-A1 AMINOALKYLPYRROLIDINYLTHIOCARBAPENEM DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-06-10 WO disclosed
EP-0545290-A1 Aminoalkylpyrrolidinylthiocarbapenem derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-06-09 EP disclosed
WO-1991014687-A1 2-(SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1991-10-03 WO disclosed
EP-0182213-B1 CARBAPENEM COMPOUNDS AND PRODUCTION THEREOF SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1990-09-26 EP disclosed