Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956250 | 0.90 | REN (0.47) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7082327 | 0.89 | REN (0.42) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7081732 | 0.88 | REN (0.41) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7080038 | 0.88 | REN (0.40) | REN | |
| SCHEMBL7079356 | 0.88 | REN (0.38) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL6947656 | 0.87 | REN (0.41) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7076946 | 0.86 | REN (0.39) | REN | |
| SCHEMBL7082632 | 0.86 | REN (0.46) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7075548 | 0.85 | REN (0.58) | REN | |
| SCHEMBL6953120 | 0.85 | REN (0.46) | RENKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |