Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLP1R | P43220 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707836 | 1.00 | ALOX5AP (0.51) | ALOX5APSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL480213 | 0.96 | ALOX5AP (0.54) | ALOX5APSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2992316 | 0.93 | SMN1; SMN2 (0.50) | ALOX5APSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL709117 | 0.86 | ALOX5AP (0.58) | ALOX5APSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL705042 | 0.86 | ALOX5AP (0.52) | ALOX5APNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL705041 | 0.86 | ALOX5AP (0.52) | ALOX5APNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL706788 | 0.83 | ALOX5AP (0.56) | ALOX5APLMNAKMT2A | |
| SCHEMBL709386 | 0.83 | ALOX5AP (0.56) | ALOX5APLMNAKMT2A | |
| SCHEMBL708415 | 0.83 | ALOX5AP (0.56) | ALOX5APSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9924152 | 0.83 | ALOX5AP (0.65) | ALOX5APNPC1RAB9AMAPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124628-B2 | Diaryl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2012-02-28 | — | — | US | claimed |
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | ALOX5, ALOX15, LTB4R2 | ALOX5AP 13/4885SMN1; SMN2 4564/4885NPC1 1015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.