Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PRCP | P42785 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448912 | 1.00 | CTRB1 (0.55) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL24322559 | 0.91 | CTRB1 (0.58) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL1372348 | 0.90 | CTRB1 (0.57) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL1372342 | 0.90 | CTRB1 (0.57) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL5859001 | 0.89 | CTRB1 (0.56) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL10706654 | 0.89 | CTRB1 (0.61) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL11459575 | 0.89 | CTRB1 (0.61) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL27280340 | 0.88 | CTRB1 (0.60) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL10784995 | 0.87 | CTRB1 (0.54) | CTRB1TSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL11450738 | 0.86 | CTRB1 (0.64) | CTRB1TSHRL3MBTL1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562977-B2 | For use in the synthesis of peptides and/or for the manufacture of pharmaceutically active substances or corresponding intermediates | HOFFMANN-LA ROCHE INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0847994-B1 | Process for the preparation of mixed anhydrides | HOFFMANN LA ROCHE (CH) | 2003-04-09 | — | — | EP | disclosed |
| US-6489479-B1 | THE PRESENT INVENTION IS CONCERNED WITH AN IMPROVED PROCESS FOR THE MANUFACTURE OF MIXED ANHYDRIDES. THE PROCESS COMPRISES ADDING AN ADJUVANT BASE TO A MIXTURE OF ACID AND REACTIVE ACID DERIVATIVE. IT IS ESPECIALLY SUITABLE FOR USE IN THE | HOFFMAN-LA ROCHE INC. | 2002-12-03 | — | — | US | disclosed |
| US-20020077481-A1 | Process for the preparation of mixed anhydrides | KARPF MARTIN (CH) | 2002-06-20 | — | — | US | disclosed |
| EP-0847994-A1 | Process for the preparation of mixed anhydrides | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-4242507-A | Sulfonic acid esters | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077481-A1 | Process for the preparation of mixed anhydrides | CA1, CA14, CA12 | CTRB1 1840/4885TSHR 1924/4885L3MBTL1 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.