Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.74 |
| ▸ | IGF1R | P08069 | 1/20 | 0.68 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.68 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.68 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 4/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078703 | 1.00 | GPR35 (0.74) | GPR35IGF1RPTPN7DUSP3PTPN12 | |
| SCHEMBL7080142 | 0.88 | PIM1 (0.73) | GPR35IGF1RPIM1PIM2AKR1B1 | |
| SCHEMBL7080145 | 0.88 | PIM1 (0.73) | GPR35IGF1RPIM1PIM2AKR1B1 | |
| SCHEMBL12891631 | 0.86 | GPR35 (0.78) | GPR35PIM1PIM2AKR1B1NPC1 | |
| SCHEMBL1248925 | 0.85 | GPR35 (1.00) | GPR35PTPN7DUSP3PTPN12PTPN22 | |
| SCHEMBL6269580 | 0.85 | GPR35 (1.00) | GPR35PTPN7DUSP3PTPN12PTPN22 | |
| SCHEMBL1248923 | 0.85 | GPR35 (1.00) | GPR35PTPN7DUSP3PTPN12PTPN22 | |
| SCHEMBL2733862 | 0.81 | PIM1 (0.81) | GPR35PIM1PIM2AKR1B1NPC1 | |
| SCHEMBL9376837 | 0.80 | PIM1 (0.73) | GPR35PIM1PIM2AKR1B1NPC1 | |
| SCHEMBL9376832 | 0.80 | PIM1 (0.73) | GPR35PIM1PIM2AKR1B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114047-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | REDDYS LAB LTD DR (IN) | 2003-03-19 | — | — | EP | disclosed |
| US-6469167-B1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-(4-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)METHOXY)BENZYL) THIAZOLIDINE-2,4-DIONE | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2002-10-22 | — | — | US | disclosed |
| EP-1114047-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000015638-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-03-23 | — | — | WO | disclosed |