Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.73 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.73 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080142 | 1.00 | PIM1 (0.73) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL7078703 | 0.88 | GPR35 (0.74) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL7078705 | 0.88 | GPR35 (0.74) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL12891631 | 0.85 | GPR35 (0.78) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL2546354 | 0.85 | PIM1 (1.00) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL1299479 | 0.85 | PIM1 (1.00) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL1299480 | 0.85 | PIM1 (1.00) | PIM1PIM2GPR35HPGDCISD1 | |
| SCHEMBL6269580 | 0.84 | GPR35 (1.00) | PIM1PIM2GPR35HPGDRAB9A | |
| SCHEMBL1248925 | 0.84 | GPR35 (1.00) | PIM1PIM2GPR35HPGDRAB9A | |
| SCHEMBL1248923 | 0.84 | GPR35 (1.00) | PIM1PIM2GPR35HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114047-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | REDDYS LAB LTD DR (IN) | 2003-03-19 | — | — | EP | disclosed |
| US-6469167-B1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-(4-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)METHOXY)BENZYL) THIAZOLIDINE-2,4-DIONE | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2002-10-22 | — | — | US | disclosed |
| EP-1114047-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000015638-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-03-23 | — | — | WO | disclosed |