Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 16/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 16/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077899 | 0.92 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BCYP2D6HRH1 | |
| SCHEMBL7965948 | 0.92 | ADRA1A (0.43) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7968224 | 0.87 | ADRA1A (0.41) | ADRA1AADRA1DADRA1BCYP2D6HRH1 | |
| SCHEMBL23778353 | 0.80 | CYP2D6 (0.47) | CYP2D6HRH1 | |
| SCHEMBL8008414 | 0.77 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7967553 | 0.77 | ADRA1A (0.39) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL8142736 | 0.77 | ADRA1A (0.39) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL8007845 | 0.76 | ADRA1A (0.48) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7955792 | 0.76 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7955794 | 0.76 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |