Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079012 | 1.00 | CCR2 (0.47) | CCR2KCNH2KDM4DCTSKSLC6A5 | |
| SCHEMBL765654 | 0.79 | CCR2 (0.56) | CCR2KDM4DCTSKHSD11B1 | |
| SCHEMBL12208931 | 0.79 | CCR2 (0.56) | CCR2KDM4DCTSKHSD11B1 | |
| SCHEMBL1699915 | 0.78 | CTSK (0.61) | CTSKHSD11B1 | |
| SCHEMBL1808105 | 0.78 | CTSK (0.61) | CTSKHSD11B1 | |
| SCHEMBL1699916 | 0.78 | CTSK (0.61) | CTSKHSD11B1 | |
| SCHEMBL7305125 | 0.78 | CCR1 (0.45) | — | |
| SCHEMBL3104685 | 0.76 | CTSK (0.58) | CTSKSLC6A5HSD11B1 | |
| SCHEMBL2876959 | 0.76 | CTSK (0.58) | CTSKSLC6A5HSD11B1 | |
| SCHEMBL803320 | 0.76 | CTSK (0.58) | CTSKSLC6A5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |