Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL7074183 | 0.85 | HSD17B10 (0.65) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL29859415 | 0.84 | HSD17B10 (1.00) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL26788 | 0.84 | HSD17B10 (1.00) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8044782 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL11125458 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL27660568 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL29289466 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8044778 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL9579917 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| Bromide SCHEMBL28560244 | 0.82 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |