Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 3/20 | 0.77 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137759 | 1.00 | OXTR (0.77) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL7137761 | 1.00 | OXTR (0.77) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL7089595 | 0.88 | OXTR (0.78) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4945256 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4936835 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4945247 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4936262 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4944776 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4944386 | 0.87 | OXTR (1.00) | OXTRAVPR1AADRB3ADRB1LMNA | |
| SCHEMBL4942988 | 0.83 | OXTR (0.71) | OXTRAVPR1AADRB3ADRB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |