Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.43 |
| ▸ | KLK7 | P49862 | 3/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075568 | 0.91 | REN (0.42) | RENKLK7KLK5TACR1CTSL | |
| SCHEMBL7081700 | 0.90 | REN (0.42) | RENTACR1 | |
| SCHEMBL7075316 | 0.88 | REN (0.45) | REN | |
| SCHEMBL7075214 | 0.85 | REN (0.43) | RENTACR1 | |
| SCHEMBL6042455 | 0.84 | REN (0.45) | RENTACR1BCHECASP1 | |
| SCHEMBL7077508 | 0.84 | REN (0.54) | REN | |
| SCHEMBL7084510 | 0.82 | REN (0.40) | RENTACR1 | |
| SCHEMBL7081233 | 0.82 | REN (0.49) | REN | |
| SCHEMBL7076955 | 0.81 | REN (0.40) | REN | |
| SCHEMBL7080889 | 0.80 | REN (0.48) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |