Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083289 | 0.87 | HMGCR (0.65) | HMGCR | |
| SCHEMBL7528668 | 0.82 | THRA (0.41) | HMGCR | |
| SCHEMBL5662499 | 0.77 | HMGCR (0.63) | HMGCR | |
| Apomine SCHEMBL1648488 | 0.75 | HMGCR (1.00) | HMGCR | |
| SCHEMBL7518927 | 0.74 | HMGCR (0.63) | HMGCR | |
| SCHEMBL21074678 | 0.72 | HMGCR (0.57) | HMGCR | |
| SCHEMBL27415462 | 0.71 | HMGCR (0.47) | HMGCR | |
| SCHEMBL7521921 | 0.71 | HMGCR (0.50) | HMGCR | |
| SCHEMBL7086181 | 0.71 | HMGCR (0.85) | HMGCR | |
| SCHEMBL13815916 | 0.71 | EGFR (0.38) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | claimed |
| EP-0845991-A2 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1998-06-10 | — | — | EP | claimed |
| WO-1997004785-A1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1997-02-13 | — | — | WO | claimed |