Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 8/20 | 0.63 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083289 | 0.83 | HMGCR (0.65) | HMGCRGSR | |
| SCHEMBL7519057 | 0.79 | GSR (0.49) | HMGCRGSRCA1CA2GABRA1 | |
| SCHEMBL10981919 | 0.78 | GSR (0.45) | HMGCRGSRMEN1KMT2ACA1 | |
| SCHEMBL1704691 | 0.78 | HMGCR (1.00) | HMGCRMEN1KMT2A | |
| SCHEMBL5664710 | 0.74 | HMGCR (0.57) | HMGCRPOLB | |
| SCHEMBL27415462 | 0.74 | HMGCR (0.47) | HMGCRGSRCA1CA2GABRA1 | |
| SCHEMBL7080284 | 0.74 | HMGCR (0.60) | HMGCR | |
| SCHEMBL7086384 | 0.73 | HMGCR (0.85) | HMGCRMEN1KMT2A | |
| SCHEMBL25922437 | 0.71 | HMGCR (0.53) | HMGCRPOLB | |
| SCHEMBL25922136 | 0.69 | HMGCR (0.56) | HMGCRMEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | claimed |
| EP-0845991-A2 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1998-06-10 | — | — | EP | claimed |
| WO-1997004785-A1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1997-02-13 | — | — | WO | claimed |