Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13212063 | 0.89 | SMN1; SMN2 (0.73) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL14025800 | 0.88 | MAPT (0.66) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL13762092 | 0.87 | MAPT (0.67) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL13766443 | 0.87 | MAPT (0.67) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL305355 | 0.86 | POLB (0.64) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL13405884 | 0.86 | TSHR (0.83) | MAPTSMN1; SMN2POLBTSHRRECQL | |
| Hydrochloric Acid SCHEMBL27826900 | 0.85 | POLB (0.63) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL14025813 | 0.85 | SLC40A1 (0.66) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL7360532 | 0.84 | MAPT (0.61) | MAPTSMN1; SMN2RAB9APOLBTSHR | |
| SCHEMBL6531634 | 0.84 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2RAB9APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322620-A1 | BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS | Neurogen Corporation (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002028839-A1 | BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2002-04-11 | — | — | WO | disclosed |