Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | BCHE | P06276 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139982 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2BCHEPKM | |
| SCHEMBL4954320 | 0.90 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL24596471 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL708285 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL7696224 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2BCHEPKM | |
| SCHEMBL29371290 | 0.84 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL87505 | 0.84 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| Water SCHEMBL5134592 | 0.82 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| Water SCHEMBL27478798 | 0.82 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL21777625 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2BCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116496-B | Synthetic method of quinoxaline heterocyclic derivative | 扬州大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-111116496-A | Synthetic method of quinoxaline heterocyclic derivative | 扬州大学 | 2020-05-08 | — | — | CN | disclosed |
| CN-109952292-A | α -amino- β -carboxyadipimic acid semialdehyde decarboxylating enzyme inhibitor | TES制药有限责任公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-105439965-A | Synthetic method of quinoxaline heterocyclic compound | JIANGSU HENGAN CHEMICAL CO LTD | 2016-03-30 | — | — | CN | disclosed |
| US-8124625-B2 | enhancing the expression of apoAI; prevention or therapy of dislipidemia | SHIONOGI & CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8053445-B2 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20090036457-A1 | Utilities of olefin derivatives | YAMAMORI TERUO | 2009-02-05 | — | — | US | disclosed |
| US-20040242615-A1 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242615-A1 | Utilities of olefin derivatives | APOL1, NR1H2, APOB | NPC1 19/4885RAB9A 4723/4885SMN1; SMN2 1814/4885 |
| US-20090036457-A1 | Utilities of olefin derivatives | APOL1, APOB, NR1H2 | NPC1 48/4885RAB9A 4606/4885SMN1; SMN2 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.