Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078933 | 0.87 | MAOB (0.35) | MEN1KMT2APOLBVCP | |
| SCHEMBL6970136 | 0.87 | MAOA (0.34) | VCP | |
| SCHEMBL7086624 | 0.86 | ACSS2 (0.34) | SMN1; SMN2 | |
| SCHEMBL6964912 | 0.85 | CYP1A2 (0.43) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6960266 | 0.85 | CYP1A2 (0.36) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6957934 | 0.84 | — | — | |
| SCHEMBL6957378 | 0.84 | — | — | |
| SCHEMBL6962737 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6968786 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6970784 | 0.83 | HSP90AA1 (0.36) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |