Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079071 | 0.90 | KDM5A (0.48) | KDM5AKDM5CKDM5BPDE9AGRIK1 | |
| SCHEMBL13279916 | 0.81 | KDM5A (0.46) | KDM5AKDM5CKDM5BPDE9AKDM4E | |
| SCHEMBL18584520 | 0.75 | FEN1 (0.51) | KDM5AKDM5CKDM5BPDE9AKDM4E | |
| SCHEMBL7160282 | 0.75 | KDM5A (0.50) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL356250 | 0.74 | KDM5A (0.49) | KDM5AKDM5CKDM5BKDM4EALDH1A1 | |
| SCHEMBL359150 | 0.73 | KDM5A (0.57) | KDM5AKDM5CKDM5BPDE9ADAO | |
| SCHEMBL2056351 | 0.73 | PDE9A (0.54) | KDM5AKDM5CKDM5BPDE9ADAO | |
| SCHEMBL2126317 | 0.71 | KDM5A (0.57) | KDM5AKDM5CKDM5BDAOPARP1 | |
| SCHEMBL7078810 | 0.70 | KDM5A (0.43) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL13913155 | 0.67 | KDM5A (0.63) | KDM5AKDM5CKDM5BPDE9ADAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059356-A2 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-24 | — | — | WO | claimed |
| WO-2003059356-A2 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |