Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 3/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | DDO | Q99489 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BIRC5 | O15392 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214164 | 0.88 | KDM5A (0.54) | KDM5AKDM5CKDM5BPDE9APDE1C | |
| SCHEMBL2126317 | 0.82 | KDM5A (0.57) | KDM5AKDM5CKDM5BDAODDO | |
| SCHEMBL359185 | 0.82 | PDE9A (0.48) | PDE9APDE1CDAODDOPIM1 | |
| SCHEMBL13913155 | 0.78 | KDM5A (0.63) | KDM5AKDM5CKDM5BPDE9APDE1C | |
| SCHEMBL7079071 | 0.76 | KDM5A (0.48) | KDM5AKDM5CKDM5BPDE9AUPP1 | |
| SCHEMBL18584520 | 0.75 | FEN1 (0.51) | KDM5AKDM5CKDM5BPDE9AMEN1 | |
| SCHEMBL7160282 | 0.75 | KDM5A (0.50) | KDM5AKDM5CKDM5BPDE9AMEN1 | |
| SCHEMBL10193365 | 0.75 | KIF11 (0.48) | PDE9APDE1CMEN1LMNAMAPT | |
| SCHEMBL13279916 | 0.74 | KDM5A (0.46) | KDM5AKDM5CKDM5BPDE9AKDM4E | |
| SCHEMBL356250 | 0.74 | KDM5A (0.49) | KDM5AKDM5CKDM5BMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023664-A1 | SULFONYL-TRIAZOLES USEFUL AS COVALENT KINASE LIGANDS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2023-02-23 | — | — | WO | disclosed |
| EP-2696682-A2 | MIF INHIBITORS AND THEIR USES | Innovimmune Biotherapeutics, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-2592933-A1 | MIF INHIBITORS AND THEIR USES | Gaweco, Anderson (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012142498-A2 | MIF INHIBITORS AND THEIR USES | INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |