Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29359033 | 0.83 | HTT (0.67) | HTTCYP3A4LMNAHDAC1HDAC2 | |
| SCHEMBL101602 | 0.83 | HTT (0.67) | HTTCYP3A4LMNAHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL30150738 | 0.82 | HTT (0.65) | HTTCYP3A4LMNAHDAC1HDAC2 | |
| SCHEMBL20867 | 0.75 | ATAD2 (0.53) | CYP3A4LMNACYP1A2TSHRHIF1A | |
| Water SCHEMBL27738785 | 0.74 | ADORA2A (0.54) | CYP3A4LMNACYP1A2TSHRHIF1A | |
| Hydrochloric Acid SCHEMBL27339406 | 0.74 | ATAD2 (0.51) | CYP3A4LMNACYP1A2TSHRHIF1A | |
| SCHEMBL27602647 | 0.72 | ATAD2 (0.49) | CYP3A4LMNACYP1A2TSHRHIF1A | |
| SCHEMBL29249244 | 0.71 | CYP3A4 (0.45) | HTTCYP3A4LMNAHDAC1HDAC2 | |
| SCHEMBL28996851 | 0.71 | CYP1A2 (0.55) | HTTCYP3A4LMNAHDAC1HDAC2 | |
| SCHEMBL29404312 | 0.71 | CYP3A4 (0.67) | HTTCYP3A4HDAC1HDAC2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003070763-A1 | METHODS AND COMPOSITIONS FOR TREATING METABOLIC BONE DISEASES RELATING TO HUMAN ENDOKINE ALPHA | HUMAN GENOME SCIENCES, INC. (US) | 2003-08-28 | — | — | WO | disclosed |