Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 4/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956650 | 0.95 | S1PR1 (0.40) | S1PR1S1PR3LNPEPNAMPTBTK | |
| SCHEMBL6955999 | 0.89 | S1PR1 (0.42) | S1PR1S1PR3LNPEPNAMPTBTK | |
| SCHEMBL6042528 | 0.86 | NAMPT (0.49) | LNPEPNAMPTBTKGPR119GRM5 | |
| SCHEMBL6042854 | 0.81 | NAMPT (0.47) | S1PR1S1PR3LNPEPNAMPTBTK | |
| SCHEMBL6953740 | 0.75 | NAMPT (0.36) | NAMPTBTKPPARAPPARGGRM5 | |
| SCHEMBL7081514 | 0.75 | L3MBTL1 (0.35) | LNPEPL3MBTL1GPR119PRMT5 | |
| SCHEMBL6042265 | 0.74 | NAMPT (0.51) | S1PR1S1PR3NAMPTBTKGPR119 | |
| SCHEMBL6957185 | 0.71 | PPARG (0.44) | NAMPTLMNAPPARAPPARG | |
| SCHEMBL6953745 | 0.71 | GRM5 (0.44) | NAMPTALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL6956024 | 0.71 | GRM5 (0.35) | NAMPTBTKKDM4EPRMT5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |