SCHEMBL7081263

SCHEMBL7081263

Cc1ccc(C(=O)NC2CCC(O)CC2)c(Nc2ccc3[nH]ncc3c2)n1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
RPS6KB1 P23443 1/20 0.51
SYK P43405 2/20 0.48
MAPK14 Q16539 1/20 0.48
ROCK2 O75116 13/20 0.48
ROCK1 Q13464 10/20 0.48
PTK2 Q05397 2/20 0.44
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7081266 1.00 RPS6KB1 (0.51) RPS6KB1SYKMAPK14ROCK2ROCK1
SCHEMBL7082077 0.88 SYK (0.52) RPS6KB1SYKMAPK14ROCK2ROCK1
SCHEMBL5409200 0.82 RPS6KB1 (0.52) RPS6KB1SYKMAPK14ROCK2ROCK1
SCHEMBL5409202 0.82 RPS6KB1 (0.52) RPS6KB1SYKMAPK14ROCK2ROCK1
SCHEMBL7078494 0.80 ROCK2 (0.53) RPS6KB1SYKROCK2ROCK1
SCHEMBL7081258 0.80 ROCK2 (0.53) SYKROCK2ROCK1
SCHEMBL7077421 0.76 ROCK2 (0.55) SYKROCK2ROCK1
SCHEMBL7079063 0.76 ROCK2 (0.55) ROCK2ROCK1POLB
SCHEMBL5415168 0.76 MAPK14 (0.67) RPS6KB1MAPK14ROCK2ROCK1
SCHEMBL5415165 0.76 MAPK14 (0.67) RPS6KB1MAPK14ROCK2ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6608058-B2 Therapeutic composition for hepatitis B, hepatitis C, or acquired immune deficiency syndrome DONG WHA PHARM. IND. CO., LTD. (KR) 2003-08-19 US claimed
US-20030092709-A1 6-Methylnicotinamide derivatives as antiviral agents DONG WHA PHARM. CO., LTD. (KR) 2003-05-15 US claimed
US-6608058-B2 Therapeutic composition for hepatitis B, hepatitis C, or acquired immune deficiency syndrome DONG WHA PHARM. IND. CO., LTD. (KR) 2003-08-19 US disclosed
US-20030092709-A1 6-Methylnicotinamide derivatives as antiviral agents DONG WHA PHARM. CO., LTD. (KR) 2003-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030092709-A1 6-Methylnicotinamide derivatives as antiviral agents TPMT, HAVCR2, NNMT RPS6KB1 645/4885SYK 4369/4885MAPK14 380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.