Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086767 | 0.93 | POLA1 (0.38) | POLA1MAPTTHRBLMNASMN1; SMN2 | |
| SCHEMBL6670559 | 0.92 | POLA1 (0.42) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL7084812 | 0.91 | POLA1 (0.38) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL7080399 | 0.85 | ABCB1 (0.37) | POLA1MAPTTHRBSMN1; SMN2ABCB1 | |
| SCHEMBL6694017 | 0.84 | POLA1 (0.40) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL7088275 | 0.83 | POLA1 (0.36) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL7087551 | 0.83 | POLA1 (0.34) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL6694556 | 0.82 | POLA1 (0.41) | POLA1MAPTTHRBKCNH2LMNA | |
| SCHEMBL6700200 | 0.82 | POLA1 (0.56) | POLA1KCNH2RAB9AKMT2AABCB1 | |
| SCHEMBL7086388 | 0.80 | ALDH1A1 (0.41) | POLA1MAPTTHRBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | claimed |