Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690723 | 0.93 | POLA1 (0.37) | CACNA1CSCN5AKCNH2HTR1DHTR1B | |
| SCHEMBL7088275 | 0.86 | POLA1 (0.36) | KCNH2POLA1MAPTKMT2ATHRB | |
| SCHEMBL6695901 | 0.85 | POLA1 (0.49) | KCNH2POLA1MEN1KMT2A | |
| SCHEMBL7086388 | 0.84 | ALDH1A1 (0.41) | POLA1MAPTTHRBRXFP1TDP1 | |
| SCHEMBL7079314 | 0.81 | ABCB1 (0.37) | POLA1MAPTTHRBTDP1 | |
| SCHEMBL6691018 | 0.80 | KCNH2 (0.42) | KCNH2POLA1MAPTMEN1KMT2A | |
| SCHEMBL6690157 | 0.80 | KCNH2 (0.42) | KCNH2POLA1MAPTMEN1KMT2A | |
| SCHEMBL6700225 | 0.79 | POLA1 (0.35) | CACNA1CSCN5AKCNH2POLA1MAPT | |
| SCHEMBL7086001 | 0.79 | POLA1 (0.34) | KCNH2POLA1MAPTMEN1KMT2A | |
| SCHEMBL6691671 | 0.78 | CACNA1C (0.35) | CACNA1CSCN5AKCNH2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | claimed |