Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 13/20 | 1.00 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.72 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.72 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | TLR4 | O00206 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | TYMS | P04818 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.72 |
| ▸ | GART | P22102 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700766 | 1.00 | DHFR (1.00) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL29430165 | 1.00 | DHFR (1.00) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL15530110 | 0.95 | DHFR (0.90) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL25725292 | 0.90 | DHFR (0.82) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL15559160 | 0.90 | DHFR (0.81) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL1021371 | 0.88 | DHFR (0.79) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL864864 | 0.88 | DHFR (0.79) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL11628330 | 0.87 | DHFR (1.00) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL12918463 | 0.87 | DHFR (1.00) | DHFRFOLR1SLC19A1SLC46A1KDM4E | |
| SCHEMBL16968756 | 0.87 | DHFR (0.80) | DHFRFOLR1SLC19A1SLC46A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030092706-A1 | Combination | NYCOMED GMBH (DE) | 2003-05-15 | — | — | US | disclosed |