Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | ACP1 | P24666 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375 | 0.75 | — | — | |
| SCHEMBL9212252 | 0.73 | HTT (0.62) | NPC1RAB9AACP1MEN1KMT2A | |
| SCHEMBL2451258 | 0.73 | — | — | |
| SCHEMBL352731 | 0.73 | — | — | |
| SCHEMBL7829112 | 0.73 | — | — | |
| SCHEMBL115951 | 0.73 | — | — | |
| SCHEMBL479906 | 0.73 | ACP1 (0.63) | NPC1RAB9AACP1MEN1KMT2A | |
| SCHEMBL9275105 | 0.72 | NPC1 (0.56) | NPC1RAB9AACP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28995499 | 0.72 | AGER (0.64) | NPC1RAB9AACP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29059238 | 0.72 | AGER (0.64) | NPC1RAB9AACP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522139-B2 | Fructose 1, 6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-12-20 | — | — | US | claimed |
| US-20130143910-A1 | Fructose-1,6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis | UNIVERSITY OF HOUSTON SYSTEM | 2013-06-06 | — | — | US | claimed |
| WO-2013074581-A1 | FRUCTOSE-1,6-BIPHOSPHATASES AS NEW TARGETS FOR DIAGNOSING AND TREATING BREAST CANCER BRAIN METASTASIS | WEIHUA ZHANG (US) | 2013-05-23 | — | — | WO | claimed |
| US-9522139-B2 | Fructose 1, 6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-12-20 | — | — | US | disclosed |
| US-20130143910-A1 | Fructose-1,6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis | UNIVERSITY OF HOUSTON SYSTEM | 2013-06-06 | — | — | US | disclosed |
| WO-2013074581-A1 | FRUCTOSE-1,6-BIPHOSPHATASES AS NEW TARGETS FOR DIAGNOSING AND TREATING BREAST CANCER BRAIN METASTASIS | WEIHUA ZHANG (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2003056922-A1 | SUBSTITUTED THIAZOLYL SULFONYL UREA COMPOUNDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-07-17 | — | — | WO | disclosed |