Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | ERN1 | O75460 | 4/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915478 | 0.83 | RELA (0.50) | ESR1ESR2APPHSD17B1HSD17B2 | |
| SCHEMBL5937446 | 0.82 | ERN1 (0.58) | ESR1ESR2CYP2A6ERN1APP | |
| SCHEMBL5937500 | 0.81 | APP (0.62) | ESR1ESR2CYP2A6ERN1APP | |
| SCHEMBL18002758 | 0.80 | ERN1 (0.41) | ESR1ESR2ERN1APPHSD17B1 | |
| SCHEMBL18003382 | 0.80 | ERN1 (0.41) | ESR1ESR2ERN1APPHSD17B1 | |
| SCHEMBL18003408 | 0.78 | HDAC6 (0.53) | ESR1ESR2ERN1APPHSD17B1 | |
| SCHEMBL18002983 | 0.78 | PTGS1 (0.41) | ESR1ESR2CYP2A6ERN1APP | |
| SCHEMBL13299955 | 0.77 | ESR1 (0.44) | ESR1ESR2CYP2A6ERN1APP | |
| SCHEMBL2150417 | 0.76 | ESR1 (0.66) | ESR1ESR2APPHSD17B1HSD17B2 | |
| SCHEMBL14077362 | 0.75 | HSD17B1 (0.46) | CYP2A6ERN1APPHSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020427-B1 | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO LTD (JP) | 2003-10-01 | — | — | EP | disclosed |
| EP-1223169-A1 | Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-07-17 | — | — | EP | disclosed |
| EP-0790246-B1 | POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-6103754-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-08-15 | — | — | US | disclosed |
| EP-1020427-A1 | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-6034119-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-03-07 | — | — | US | disclosed |
| US-5968935-A | ADMINISTERING TO TREAT NERVOUS SYSTEM DISORDERS | TOYAMA CHEMICAL CO.., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| US-5932620-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5922721-A | USE IN TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S CHOREA, AMYOTROPHIC LATERAL SCLEROSIS AND TRAUAMTIC NERVE INJURIES | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| US-5807887-A | COGNITION ACTIVATOR; ALZHEIMER*S, HUNTINGTON DISEASE | TOYAMA CHEMICAL CO., LTD. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0790246-A1 | POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-08-20 | — | — | EP | disclosed |