Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813837 | 0.91 | REN (0.63) | RENCYP3A4KCNH2 | |
| SCHEMBL695813 | 0.90 | REN (0.57) | RENCYP3A4KCNH2 | |
| SCHEMBL2814538 | 0.88 | REN (0.57) | RENCYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL700945 | 0.88 | REN (0.57) | RENCYP3A4 | |
| Hydrochloric Acid SCHEMBL9952035 | 0.87 | REN (0.54) | RENCYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL9952099 | 0.86 | REN (0.55) | RENCYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL700661 | 0.85 | REN (0.77) | RENCYP3A4 | |
| SCHEMBL694310 | 0.83 | REN (0.51) | RENCYP3A4KCNH2 | |
| SCHEMBL2818546 | 0.82 | REN (0.60) | RENCYP3A4 | |
| Hydrochloric Acid SCHEMBL708306 | 0.82 | REN (0.60) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |