Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 2/20 | 0.30 |
| ▸ | YAP1 | P46937 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076766 | 0.93 | REN (0.54) | RENSSTR5PDE4B | |
| SCHEMBL7079908 | 0.93 | REN (0.52) | RENSSTR5PDE4B | |
| SCHEMBL7079907 | 0.89 | REN (0.43) | RENSSTR5PDE4BTACR1 | |
| SCHEMBL7078446 | 0.89 | REN (0.51) | RENSSTR5PDE4B | |
| SCHEMBL7084760 | 0.89 | REN (0.54) | RENSSTR5PDE4BALDH1A1 | |
| SCHEMBL7079331 | 0.89 | REN (0.46) | RENSSTR5PDE4BADAM17 | |
| SCHEMBL7084145 | 0.88 | REN (0.49) | RENSSTR5PDE4B | |
| SCHEMBL7079511 | 0.88 | REN (0.54) | RENPDE4B | |
| SCHEMBL7077001 | 0.88 | REN (0.45) | RENADAM17 | |
| SCHEMBL7074869 | 0.88 | REN (0.44) | RENSSTR5PDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |