Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.31 |
| ▸ | MGAM | O43451 | 3/20 | 0.31 |
| ▸ | SI | P14410 | 3/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074869 | 0.90 | REN (0.44) | RENSSTR5PDE4B | |
| SCHEMBL7076766 | 0.90 | REN (0.54) | RENSSTR5PDE4B | |
| SCHEMBL7079908 | 0.90 | REN (0.52) | RENSSTR5PDE4B | |
| SCHEMBL7079907 | 0.89 | REN (0.43) | RENSSTR5PDE4B | |
| SCHEMBL7084760 | 0.89 | REN (0.54) | RENSSTR5PDE4BMAPT | |
| SCHEMBL7082883 | 0.89 | REN (0.46) | RENSSTR5PDE4BADAM17 | |
| SCHEMBL7078446 | 0.87 | REN (0.51) | RENSSTR5PDE4B | |
| SCHEMBL7079511 | 0.87 | REN (0.54) | RENPDE4B | |
| SCHEMBL7084145 | 0.87 | REN (0.49) | RENSSTR5PDE4B | |
| SCHEMBL7081735 | 0.87 | REN (0.63) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |