Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083354 | 0.84 | KDM4E (0.52) | ALDH1A1HPGDKDM4ESMN1; SMN2POLB | |
| SCHEMBL6042146 | 0.80 | PLA2G2A (0.45) | ALDH1A1HPGDKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL6042018 | 0.78 | PDE4A (0.36) | ALDH1A1HPGDKDM4ESMN1; SMN2PDE10A | |
| SCHEMBL6042263 | 0.76 | PDE10A (0.35) | ALDH1A1HPGDKDM4ESMN1; SMN2TSHR | |
| SCHEMBL8577459 | 0.75 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4ESMN1; SMN2TSHR | |
| SCHEMBL4419587 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HPGDKDM4ESMN1; SMN2MTNR1A | |
| SCHEMBL8216043 | 0.75 | KCNA3 (0.46) | ALDH1A1MTNR1AMTNR1BL3MBTL1RECQL | |
| SCHEMBL31286516 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4ESMN1; SMN2POLB | |
| SCHEMBL7058048 | 0.74 | KDM4E (0.52) | ALDH1A1HPGDKDM4EPOLBCASP6 | |
| SCHEMBL9127984 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |