Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.46 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20863587 | 0.86 | HAO1 (0.57) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL8527467 | 0.85 | HAO1 (0.64) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL2258847 | 0.84 | IGF1R (0.53) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL11224194 | 0.83 | HAO1 (0.77) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL14360065 | 0.82 | HAO1 (0.64) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL13444088 | 0.79 | GID4 (0.72) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL7324670 | 0.79 | GID4 (0.72) | HAO1MAPK1MAPK14GID4KMT2A | |
| SCHEMBL11224856 | 0.78 | HAO1 (1.00) | HAO1MAPK1MAPK14KMT2AMEN1 | |
| Water SCHEMBL11227423 | 0.77 | HAO1 (0.98) | HAO1MAPK1MAPK14KMT2AMEN1 | |
| Water SCHEMBL11227425 | 0.77 | HAO1 (0.98) | HAO1MAPK1MAPK14KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |