Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083561 | 0.72 | CYP1A1 (0.39) | DNMT1KMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL7083557 | 0.72 | CYP1A1 (0.39) | DNMT1KMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL8335512 | 0.72 | PDE4B (0.46) | DNMT1KMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL6972866 | 0.72 | PDE4B (0.58) | KMT2AMEN1PDE4BALDH1A1HPGD | |
| SCHEMBL6972871 | 0.72 | PDE4B (0.58) | KMT2AMEN1PDE4BALDH1A1HPGD | |
| SCHEMBL6966726 | 0.70 | XDH (0.60) | KMT2AMEN1HDAC1HDAC2HDAC8 | |
| SCHEMBL6966722 | 0.70 | XDH (0.60) | KMT2AMEN1HDAC1HDAC2HDAC8 | |
| SCHEMBL6583878 | 0.69 | PDE4B (0.43) | DNMT1KMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL6583882 | 0.69 | PDE4B (0.46) | DNMT1KMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL6583873 | 0.69 | PDE4B (0.43) | DNMT1KMT2AMEN1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |