Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083561 | 1.00 | CYP1A1 (0.39) | CYP1A1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL7083564 | 0.72 | DNMT1 (0.39) | CYP1A1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL6966722 | 0.71 | XDH (0.60) | CYP1A1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL6966726 | 0.71 | XDH (0.60) | CYP1A1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL8335512 | 0.70 | PDE4B (0.46) | MEN1KMT2AHDAC1HDAC2HDAC8 | |
| SCHEMBL6972866 | 0.70 | PDE4B (0.58) | MEN1KMT2APDE4BALDH1A1HPGD | |
| SCHEMBL6972871 | 0.70 | PDE4B (0.58) | MEN1KMT2APDE4BALDH1A1HPGD | |
| SCHEMBL29096342 | 0.68 | KDM4E (0.57) | MEN1KMT2AHDAC1HDAC2HDAC8 | |
| SCHEMBL16960211 | 0.68 | ALDH1A1 (0.47) | CYP1A1PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL6587547 | 0.68 | MMP9 (0.58) | CYP1A1PTGS1PTGS2HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |