Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.32 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084717 | 0.98 | HMGCR (0.48) | HMGCRNR1I2GAAEPHX2NR5A2 | |
| SCHEMBL7133476 | 0.91 | HMGCR (0.50) | HMGCRNR1I2 | |
| SCHEMBL7133257 | 0.89 | HMGCR (0.62) | HMGCRNR1I2GAAEPHX2ALDH1A1 | |
| SCHEMBL9357992 | 0.80 | HMGCR (0.39) | HMGCRNR1I2GAAALDH1A1 | |
| SCHEMBL7134552 | 0.79 | HMGCR (0.76) | HMGCRNR1I2GAANR5A2NR5A1 | |
| SCHEMBL7083305 | 0.78 | GAA (0.38) | HMGCRGAAEPHX2ALDH1A1 | |
| SCHEMBL9358093 | 0.74 | HMGCR (0.48) | HMGCRNR1I2NR5A2NR5A1 | |
| SCHEMBL7084485 | 0.72 | HMGCR (0.48) | HMGCRNR1I2NR5A2NR5A1 | |
| SCHEMBL7083916 | 0.71 | HMGCR (0.80) | HMGCRNR1I2GAAALDH1A1ATM | |
| SCHEMBL7084572 | 0.71 | HMGCR (0.40) | HMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |