Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083305 | 0.93 | GAA (0.38) | HMGCRTHRATHRBMEN1KMT2A | |
| SCHEMBL7080263 | 0.90 | HMGCR (0.42) | HMGCRTHRATHRBHSD11B1HSD17B2 | |
| SCHEMBL7079979 | 0.82 | HMGCR (0.42) | HMGCRTHRATHRBKMT2A | |
| SCHEMBL7133476 | 0.75 | HMGCR (0.50) | HMGCR | |
| SCHEMBL7083572 | 0.71 | HMGCR (0.48) | HMGCRALDH1A1 | |
| SCHEMBL7140544 | 0.69 | NR1I2 (0.37) | HMGCRMEN1KMT2AHSD11B1HSD17B2 | |
| SCHEMBL11267610 | 0.69 | MAOB (0.42) | THRATHRBKDM4EALDH1A1HPGD | |
| SCHEMBL6451333 | 0.68 | PPARA (0.46) | — | |
| SCHEMBL31207205 | 0.68 | TYR (0.51) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7086380 | 0.68 | HMGCR (0.41) | HMGCRMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |